A natural sesquiterpene with diverse biological activity; lethal against ticks

(+)-Nootkatone – 50 mg

Brand:
Cayman
CAS:
4674-50-4
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Nootkatone is sesquiterpene ketone originally isolated from grapefruit juice and peel oil with diverse biological activity.{39763,39764} It is lethal against ticks, fleas, and mosquitoes with LC50 values of 0.0029, 0.0061, and 0.0046% w/v, respectively.{39764} Pretreatment of wood with (+)-nootkatone reduces tunnel lengths, feeding, and survival rates in C. formosanus termites.{39765} (+)-Nootkatone (10-100 µM) dose-dependently activates AMPKα1 and AMPKα2 in C2C12 mouse myoblast lysate containing a substrate peptide.{39766} It dose-dependently inhibits platelet aggregation induced by collagen, thrombin (Item No. 13188), and arachidonic acid (Item No. 90010) when used at concentrations ranging from 10 to 100 μM with almost complete inhibition at the highest concentration.{39767} In vivo, (+)-nootkatone (3-30 mg/kg, p.o.) dose-dependently increases the length of tail bleeding time in mice. (+)-Nootkatone (0.1-0.3%, p.o.) dose-dependently reduces body weight and plasma glucose levels in mice fed a high-fat and high-sucrose diet.{39766}  

 

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Description

A natural sesquiterpene with diverse biological activity; lethal against ticks, fleas, and mosquitoes (LC50s = 0.0029, 0.0061, and 0.0046% w/v, respectively); reduces tunnel lengths, feeding, and survival rates in C. formosanus termites; dose-dependently activates AMPKα1 and AMPKα2 in C2C12 mouse myoblast lysate containing a substrate peptide from 10-100 μM; inhibits platelet aggregation induced by collagen, thrombin, and arachidonic acid from 10-100 μM; dose-dependently increases the length of tail bleeding time in mice from 3-30 mg/kg; reduces body weight and plasma glucose levels in mice fed a high-fat and high-sucrose diet ,

Formal name: (4R,4aS,6R)-4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-2(3H)-naphthalenone

Synonyms: 

Molecular weight: 218.3

CAS: 4674-50-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Toxicology|Environmental

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