Description
A depolarizing neuromuscular blocking agent; a partial agonist of muscle-type nAChRs; activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes (EC50 = 40 µM); a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors (IC50s = 7.4, 405, 28, and 59 µM, respectively); a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor); inhibits electric eel AChE; blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively
Formal name: N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide
Synonyms:
Molecular weight: 418.3
CAS: 541-22-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience
