A depolarizing neuromuscular blocking agent; a partial agonist of muscle-type nAChRs; activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes (EC50 = 40 µM); a nondepolarizing antagonist of neuronal-type nAChRs

Decamethonium (bromide) – 1 g

Brand:
Cayman
CAS:
541-22-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Decamethonium is a depolarizing neuromuscular blocking agent.{42107} It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs).{42108} Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 µM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 µM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor).{27173} It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively.{42107,19407} Formulations containing decamethonium have been used to induce paralysis during anesthesia.  

 

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SKU: 24907 - 1 g Category:

Description

A depolarizing neuromuscular blocking agent; a partial agonist of muscle-type nAChRs; activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes (EC50 = 40 µM); a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors (IC50s = 7.4, 405, 28, and 59 µM, respectively); a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor); inhibits electric eel AChE; blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively

Formal name: N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide

Synonyms: 

Molecular weight: 418.3

CAS: 541-22-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience

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