A DHA-derived SPM; increases phagocytosis of E. coli or apoptotic neutrophils in isolated human monocyte-derived macrophages at 10 nM; decreases LTB4-induced chemotaxis of isolated human neutrophils at 10 nM; accelerates tissue regeneration in planaria at 1 and 10 nM; shortens the inflammatory resolution period and decreases inflammatory exudate neutrophil infiltration in a mouse model of E. coli-induced peritonitis at 100 ng/animal

RCTR1 – 100 µg

Brand:
Cayman
CAS:
2095607-49-9
Storage:
-80
UN-No:
Excepted Quantity - 1170 / 3

Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid (DHA; Item No. 90310) by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.{54253} It has been found in human spleen and bone marrow.{54255} RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.{54253,54255,54254} RCTR1 (10 nM) increases phagocytosis of E. coli or apoptotic neutrophils in isolated human monocyte-derived macrophages.{54255} It decreases chemotaxis induced by leukotriene B4 (LTB4; Item No. 20110) in isolated human neutrophils when used at a concentration of 10 nM. RCTR1 (1 and 10 nM) accelerates tissue regeneration in planaria. Intraperitoneal administration of RCTR1 (100 ng/animal) shortens the inflammatory resolution period and decreases inflammatory exudate neutrophil infiltration in a mouse model of E. coli-induced peritonitis.  

 

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SKU: 24896 - 100 µg Category:

Description

A DHA-derived SPM; increases phagocytosis of E. coli or apoptotic neutrophils in isolated human monocyte-derived macrophages at 10 nM; decreases LTB4-induced chemotaxis of isolated human neutrophils at 10 nM; accelerates tissue regeneration in planaria at 1 and 10 nM; shortens the inflammatory resolution period and decreases inflammatory exudate neutrophil infiltration in a mouse model of E. coli-induced peritonitis at 100 ng/animal

Formal name: (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-8-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-7,17-dihydroxydocosa-4,9,11,13,15,19-hexaenoic acid

Synonyms:  Resolvin Glutathione Conjugate in Tissue Regeneration 1|Resolvin Sulfido Conjugate 1

Molecular weight: 665.8

CAS: 2095607-49-9

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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