A mixture of hydroxy and non-hydroxy globotriaosylceramides isolated from porcine RBCs; found in mammalian cell membranes; act as receptors for Shiga and Shiga-like toxins in vitro and in vivo; accumulate in various cells in patients with Fabry disease; interacts with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes

Globotriaosylceramides (porcine) – 10 mg

Brand:
Cayman
CAS:
71965-57-6
Storage:
-20
UN-No:
Non-Hazardous - /

Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides (Item No. 16983).{38975} They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo.{38976} Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.{38977} Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes.{38975} This product contains a mixture of hydroxy and non-hydroxy fatty acid-containing globotriaosylceramides isolated from porcine red blood cells (RBCs). [Matreya, LLC. Catalog No. 1067]  

 

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SKU: 24870 - 10 mg Category:

Description

A mixture of hydroxy and non-hydroxy globotriaosylceramides isolated from porcine RBCs; found in mammalian cell membranes; act as receptors for Shiga and Shiga-like toxins in vitro and in vivo; accumulate in various cells in patients with Fabry disease; interacts with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes,

Formal name: 1-O-(O-α-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl)-ceramide

Synonyms:  Ceramide Trihexosides (porcine)

Molecular weight: 1,136.60

CAS: 71965-57-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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