A sulfatide; interacts with LMIR5 to increase activation of NFAT; an immunodominant species that is bound by CD1d in vitro; reduces symptoms

C24:1 3′-sulfo Galactosylceramide (d18:1/24:1(15Z)) – 1 mg

Brand:
Cayman
CAS:
151057-28-2
Storage:
-20
UN-No:
Non-Hazardous - /

C24:1 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3’-sulfo galactosylceramide (Item No. 24351) in rat cerebellum from seven to 32 days of age when active myelination occurs.{41714} It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5.{41715} It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay via LMIR5. C24:1 3’-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d in vitro, and increases proliferation in isolated mouse splenocytes.{40651} It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 µg.{41716} It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice. [Matreya, LLC. Catalog No. 1931]  

 

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Description

A sulfatide; interacts with LMIR5 to increase activation of NFAT; an immunodominant species that is bound by CD1d in vitro; reduces symptoms, increases survival, and decreases inflammatory lesions in a mouse model of chronic relapsing-remitting EAE (20 µg)

Formal name: N-[(1S)-2R-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3E-heptadecen-1-yl]-15Z-tetracosenamide

Synonyms:  (3’-sulfo)Galβ-Cer(d18:1/24:1)|cis-Tetracosenoyl Sulfatide|C24:1 Sulfatide|N-Nervonoyl Sulfatide|N-Tetracosenoyl (cis-15) Sulfatide

Molecular weight: 890.3

CAS: 151057-28-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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