Urocortin II (human) (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
398001-88-2
Storage:
-20
UN-No:
Non-Hazardous - /

Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF (Item No. 24407), urocortin (Item No. 24745), urocortin III (Item Nos. 24749 | 24750), frog sauvagine, and piscine urotensin I.{38848} Human urocortin II shares 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin (Item No. 24744), and human urocortin III (Item No. 24748). Urocortin II increases cell shortening and accelerates relaxation of rabbit ventricular myocytes in a time- and concentration-dependent manner. In vivo, urocortin reduces arterial blood pressure in normotensive and spontaneously hypertensive rats via peripheral CRF2 receptor agonism. It induces dose-dependent tachycardia and hypotension in rats when administered at doses of 3 and 30 pmol/kg.{38849} Urocortin (10 and 20 μg/kg) also reduces the visceral pain response to colorectal distension in conscious rats and delays gastric emptying in mice.{38848,38850}  

 

Available on backorder

SKU: 24746 - 1 mg Category:

Description

A neuropeptide hormone; increases cell shortening and accelerates relaxation of rabbit ventricular myocytes in a time- and concentration-dependent manner; reduces arterial blood pressure in normotensive and spontaneously hypertensive rats; induces dose-dependent tachycardia and hypotension in rats (3 and 30 pmol/kg); reduces the visceral pain response to colorectal distension in conscious rats (10 and 20 μg/kg); delays gastric emptying in mice,


Formal name: L-isoleucyl-L-valyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-arginyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-threonyl-L-threonyl-L-asparaginyl-L-alanyl-L-arginyl-L-isoleucyl-L-leucyl-L-alanyl-L-arginyl-L-valylglycyl-L-histidyl-L-cysteine, trifluoroacetate salt

Synonyms: 

Molecular weight: 4,450.20

CAS: 398001-88-2

Purity: ≥95%

Formulation: A lyophilized powder


Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Pain Research