Description
A neuropeptide hormone; binds to type 1 and 2 CRF receptors as well as CRF-BP (Kis = 0.16, 0.41, and 0.10 nM for CRF1, CRF2β, and CRF-BP, respectively); induces cAMP production in CHO cells expressing CRF1 and CRF2β (EC50s = 0.8 and 0.18 nM, respectively) and secretion of ACTH by rat anterior pituitary cells (EC50 = 0.006 nM); decreases mean arterial pressure and increases plasma levels of ACTH in rats (0.94-18.85 μg/kg); inhibits gastric emptying of a solid meal in mice and rats and inhibits gastric motility and transit induced by vagal stimulation in rats; mRNA levels increase in testis in response to ischemia-reperfusion injury in a rat model of testicular torsion,
Formal name: L-α-aspartyl-L-α-aspartyl-L-prolyl-L-prolyl-L-leucyl-L-seryl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-α-aspartyl-L-seryl-L-valinamide, trifluoroacetate salt
Synonyms:
Molecular weight: 4,707.30
CAS: 171543-83-2
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neuroendocrinology
