An atypical sphingolipid; contains a double bond at the 4E native position; is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis; levels are elevated in paclitaxel treated u87 astroglioma cells; plasma levels are increased in patients with CIAP and DSPN

1-Deoxysphingosine (m18:1(4E)) – 1 mg

Brand:
Cayman
CAS:
193222-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.{40307,42289} Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).{53418}  

 

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SKU: 24687 - 1 mg Category:

Description

An atypical sphingolipid; contains a double bond at the 4E native position; is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis; levels are elevated in paclitaxel treated u87 astroglioma cells; plasma levels are increased in patients with CIAP and DSPN

Formal name: 2S-amino-4E-octadecen-3R-ol

Synonyms:  1-deoxySO|4E-1-Deoxysphingosine (m18:1)

Molecular weight: 283.5

CAS: 193222-34-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Pain Research

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