An Hsp90 inhibitor; binds to Hspα and Hspβ (IC50s = 100 and 103 nM

CUDC-305 – 1 mg

Brand:
Cayman
CAS:
1061318-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

CUDC-305 is an orally bioavailable inhibitor of heat shock protein 90 (Hsp90; Item Nos. 22734 | 22735).{43002} It binds to Hsp90α and Hsp90β (IC50s = 100 and 103 nM for purified protein, respectively) as well as Hsp90 isolated from non-small cell lung cancer (NSCLC) cells resistant to erlotinib (Item No. 10483; IC50 = 70 nM).{43002,43003} CUDC-305 induces degradation of Hsp90 client proteins in BT-474 breast cancer cells and inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM).{43002} It also reduces the levels of several oncoproteins including Akt and phosphorylated Akt, and ERK1/2 and phosphorylated ERK1/2 in a variety of cancer cell lines. CUDC-305 (40-160 mg/kg) dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model and, when administered at a dose of 160 mg/kg, prolongs survival in a U87MG mouse orthotopic model.  

 

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SKU: 24683 - 1 mg Category:

Description

An Hsp90 inhibitor; binds to Hspα and Hspβ (IC50s = 100 and 103 nM, respectively) and Hsp90 isolated from erlotinib-resistant NSCLC cells (IC50 = 70 nM); inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM); dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model at 40-160 mg/kg; prolongs survival in a U87MG mouse orthotopic model at 160 mg/kg

Formal name: 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-1H-imidazo[4,5-c]pyridine-1-ethanamine

Synonyms: 

Molecular weight: 442.6

CAS: 1061318-81-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer

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