An inhibitor of FGFR1 (IC50 = 40 nM); selective for FGFR1 over PDGFβ and EGFR (IC50s = 262 and 3

PD 161570 – 10 mg

Brand:
Cayman
CAS:
192705-80-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

PD 161570 is an inhibitor of FGF receptor 1 (FGFR1; IC50 = 40 nM).{39833} It is selective for FGFR1 over PDGF receptor β (PDGFβ) and the EGF receptor (EGFR; IC50s = 262 and 3,700 nM, respectively). PD 161570 inhibits constitutive phosphorylation of FGFR1 in Sf9 insect cells overexpressing human FGFR1 and in A121 ovarian carcinoma cells and inhibits growth of A121 cells in a time-dependent manner.  

 

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SKU: 24681 - 10 mg Category:

Description

An inhibitor of FGFR1 (IC50 = 40 nM); selective for FGFR1 over PDGFβ and EGFR (IC50s = 262 and 3,700 nM, respectively); inhibits constitutive phosphorylation of FGFR1 in Sf9 insect cells overexpressing human FGFR1 and in A121 ovarian carcinoma cells; inhibits growth of A121 cells in a time-dependent manner,

Formal name: N-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)-urea

Synonyms: 

Molecular weight: 532.5

CAS: 192705-80-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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