Description
An inhibitor of FGFR1 (IC50 = 40 nM); selective for FGFR1 over PDGFβ and EGFR (IC50s = 262 and 3,700 nM, respectively); inhibits constitutive phosphorylation of FGFR1 in Sf9 insect cells overexpressing human FGFR1 and in A121 ovarian carcinoma cells; inhibits growth of A121 cells in a time-dependent manner,
Formal name: N-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)-urea
Synonyms:
Molecular weight: 532.5
CAS: 192705-80-9
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
