A non-steroidal antiandrogen; binds to the androgen receptor (Kd = 1.8

RU-58841 – 50 mg

Brand:
Cayman
CAS:
154992-24-2
Storage:
-20
UN-No:
Non-Hazardous - /

RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively).{41776} In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.{41777}  

 

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SKU: 24680 - 50 mg Category:

Description

A non-steroidal antiandrogen; binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively); reduces size of the flank organ without affecting sex organs in hamsters topically from 1-100 μg/animal; no effect on sex organ weight in intact rats up to 1 mg/animal; induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques at 5% v/v, topical

Formal name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile

Synonyms: 

Molecular weight: 369.3

CAS: 154992-24-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens

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