A selective Nav1.1 and Nav1.3 channel blocker (IC50s = 10

ICA 121431 – 5 mg

Brand:
Cayman
CAS:
313254-51-2
Storage:
-20
UN-No:
Non-Hazardous - /

ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively).{36656} It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.  

 

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SKU: 24669 - 5 mg Category:

Description

A selective Nav1.1 and Nav1.3 channel blocker (IC50s = 10,000 nM for Nav1.1, Nav1.3, Nav1.4, and Nav1.5-1.8, respectively); induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at 1 μM; substitution of the Nav1.3 VSD4 with the Nav1.5 VSD4 reduces potency by ~500-fold

Formal name: α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide

Synonyms: 

Molecular weight: 449.5

CAS: 313254-51-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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