A caspase-8 substrate; cleavage of the IETD peptide sequence releases p-nitroalinide

Ac-IETD-pNA – 1 mg

Brand:
Cayman
CAS:
219138-21-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ac-IETD-pNA is a substrate for caspase-8.{38794} Caspase-8 preferentially binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.  

 

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SKU: 24568 - 1 mg Category:

Description

A caspase-8 substrate; cleavage of the IETD peptide sequence releases p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity

Formal name: N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)-L-α-asparagine

Synonyms:  Ac-Ile-Glu-Thr-Asp-pNA|Caspase-8 Chromogenic Substrate I

Molecular weight: 638.6

CAS: 219138-21-3

Purity: ≥95%

Formulation: A lyophilized powder

Application|Enzyme Activity||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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