A neuropeptide and agonist of NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM

Neuropeptide FF (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
99566-27-5
Storage:
-20
UN-No:
Non-Hazardous - /

Neuropeptide FF (NPFF) is a peptide expressed in the brain and spinal cord that shares a precursor protein with neuropeptide AF.{38823} NPFF is expressed primarily in the posterior pituitary, hypothalamus, and medulla. It is an agonist at NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively, for human recombinant receptors) that inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively).{38824} NPFF activates parvocellular neurons in the paraventricular nucleus (PVN) of the hypothalamus to stimulate oxytocin release from their projections in the brain stem, thereby regulating baroreflex control of heart rate.{38825} However, it inhibits magnocellular PVN neurons by enhancing GABAergic input. It is also found in plasma and exogenous administration briefly increases mean arterial pressure (MAP) by 40 mm Hg in rats, an effect that is only partially blocked by the norepinephrine competitor guanethidine (Item No. 16217) and the α1-adrenergic receptor antagonist prazosin (Item No. 15023).{38826} NPFF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats.{38823,38827} It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol.{38828}  

 

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Description

A neuropeptide and agonist of NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively for human recombinant receptors); inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively); regulates baroreflex control of heart rate by activating oxytocin-releasing parvocellular PVN neurons; inhibits magnocellular PVN neurons; increases MAP briefly by 40 mm Hg in rats; has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats; also inhibits acquisition of conditioned place preference to cocaine in rats (10 and 20 nmol)

Formal name: L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt

Synonyms:  NPFF

Molecular weight: 1,081.30

CAS: 99566-27-5

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Heart||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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