A bicyclic monoterpene with diverse biological activities; inhibits proliferation of B16/F10-Nex2 mouse melanoma

(±)-Camphene – 100 mg

Brand:
Cayman
CAS:
79-92-5
Storage:
-20
UN-No:
De Minimis - 1325 / 4.1

(±)-Camphene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has diverse biological activities, including antiproliferative, pro-apoptotic, hypolipidemic, and insecticidal properties.{42303,47119,47120,47121,47122} It inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (IC50s = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively).{47119} (±)-Camphene (70 μg/ml) increases caspase-3 activity and induces apoptosis and endoplasmic reticulum stress in B16/F10-Nex2 cells. It lowers plasma levels of total cholesterol, LDL cholesterol, and triglycerides (TGs) in a Triton WR-1339-induced rat model of hyperlipidemia when administered at a dose of 1.5 μg/g.{47120} Dietary administration of (±)-camphene (0.2%) also inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity.{47121} It also has larvicidal activity against third instar H. armigera larvae (LC50 = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC50 = 35.39 μg/ml).{47122} Formulations containing (±)-camphene have been used as perfume and food additives.  

 

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Description

A bicyclic monoterpene with diverse biological activities; inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (IC50s = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively); increases caspase-3 activity and induces apoptosis and ER stress in B16/F10-Nex2 cells at 70 μg/ml; lowers plasma levels of total cholesterol, LDL cholesterol, and TGs in a Triton WR-1339-induced rat model of hyperlipidemia at 1.5 μg/g; inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity at 0.2%, dietary; has larvicidal activity against third instar H. armigera larvae (LC50 = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC50 = 35.39 μg/ml)

Formal name: 2,2-dimethyl-3-methylene-bicyclo[2.2.1]heptane

Synonyms:  DL-Camphene|NSC 4165

Molecular weight: 136.2

CAS: 79-92-5

Purity: ≥97%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Pesticides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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