A cell-permeable analog of naturally occurring ceramides; stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor (10 μM); induces cell cycle arrest in the G0G1 phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells

C2 L-erythro Ceramide (d18:1/2:0) – 1 mg

Brand:
Cayman
CAS:
150338-90-2
Storage:
-20
UN-No:
Non-Hazardous - /

C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides.{37337} It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is >50% less than that stimulated by C2 ceramide (Item No. 62510). C2 L-erythro Ceramide also induces cell cycle arrest in the G0G1 phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.{37336,37339} [Matreya, LLC. Catalog No. 1847]  

 

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SKU: 24387 - 1 mg Category:

Description

A cell-permeable analog of naturally occurring ceramides; stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor (10 μM); induces cell cycle arrest in the G0G1 phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells

Formal name: N-[(1R,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide

Synonyms:  L-erythro Cer(d18:1/2:0)|L-erythro Ceramide (d18:1/2:0)|N-acetyl-L-erythro-Sphingosine

Molecular weight: 341.5

CAS: 150338-90-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Cycle|G1||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Lipid Biochemistry|Sphingolipids

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