A cell-permeable analog of naturally occurring ceramides; stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor (10 μM); inhibits IL-4 production by 17% in EL4 T cells stimulated with PMA when used at a concentration of 10 μM; induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells

C2 L-threo Ceramide (d18:1/2:0) – 1 mg

Brand:
Cayman
CAS:
143615-69-4
Storage:
-20
UN-No:
Non-Hazardous - /

C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{37337} It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide (Item No. 62510). C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 10 μM.{13011} It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.{37336,37339} [Matreya, LLC. Catalog No. 1829]  

 

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SKU: 24386 - 1 mg Category:

Description

A cell-permeable analog of naturally occurring ceramides; stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor (10 μM); inhibits IL-4 production by 17% in EL4 T cells stimulated with PMA when used at a concentration of 10 μM; induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells,

Formal name: N-[(1S,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide

Synonyms:  L-threo Cer(d18:1/2:0)|L-threo Ceramide (d18:1/2:0)|N-acetyl-L-threo-Sphingosine

Molecular weight: 341.5

CAS: 143615-69-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Cycle|G1||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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