A bioactive sphingolipid; synthetic stereoisomer of sphingosine; inhibits PKC in vitro (IC50 = 3.3 mol%); inhibits PMA-induced superoxide generation in neutrophils and reduces growth of CHO cells (IC50s = 1.3 and 2 μM

L-erythro Sphingosine (d18:1) – 500 µg

Brand:
Cayman
CAS:
6036-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) (Item No. 10007907). It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 μM, respectively).{15200} L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb; EC50 = 5 μM) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 μM).{41482}  

 

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SKU: 24372 - 500 µg Category:

Description

A bioactive sphingolipid; synthetic stereoisomer of sphingosine; inhibits PKC in vitro (IC50 = 3.3 mol%); inhibits PMA-induced superoxide generation in neutrophils and reduces growth of CHO cells (IC50s = 1.3 and 2 μM, respectively); inhibits dephosphorylation of pRB (EC50 = 5 μM) and growth of MOLT-4 cells (IC50 = 3.7 μM)

Formal name: (2R,3S,4E)-2-amino-4-octadecene-1,3-diol

Synonyms:  L-erythro Sphingosine|L-erythro-C18-Sphingosine

Molecular weight: 299.5

CAS: 6036-75-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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