An FKBP51 inhibitor (Ki = 6 nM); highly selective for FKBP51 over FKBP52 (Ki = >50

SAfit2 – 5 mg

Brand:
Cayman
CAS:
1643125-33-0
Storage:
-20
UN-No:
Non-Hazardous - /

SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM).{40930} It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; Item No. 24407). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.{40931}  

 

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SKU: 24366 - 5 mg Category:

Description

An FKBP51 inhibitor (Ki = 6 nM); highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM); decreases plasma corticosterone levels to a greater extent than control mice following dexamethasone administration (20 mg/kg); does not increase plasma corticosterone levels as high as in control mice following administration of CRF (20 mg/kg); has antidepressant-like and anxiolytic-like activity in mice (20 mg/kg)

Formal name: (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]-2-piperidinecarboxylic acid, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester

Synonyms: 

Molecular weight: 803

CAS: 1643125-33-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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