A biotin-conjugated pan-caspase inhibitor; an affinity probe that allows for detection and immobilization of caspases using the biotin ligand; inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD; binds to caspase-3 and caspase-8 in hepatocyte lysates

Biotin-VAD-FMK – 1 mg

Brand:
Cayman
CAS:
1135688-15-1
Storage:
-20
UN-No:
Non-Hazardous - /

Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK (Item No. 14467).{9853} It is an affinity probe that allows for detection and immobilization of caspases using the biotin ligand. Biotin-VAD-FMK inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD. It also binds to caspase-3 and caspase-8 in hepatocyte lysates, an effect that can be blocked by the caspase inhibitor Ac-DEVD-CHO (Item No. 10017).  

 

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SKU: 24305 - 1 mg Category:

Description

A biotin-conjugated pan-caspase inhibitor; an affinity probe that allows for detection and immobilization of caspases using the biotin ligand; inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD; binds to caspase-3 and caspase-8 in hepatocyte lysates,

Formal name: methyl (3S,6S,9S)-3-(2-fluoroacetyl)-9-isopropyl-6-methyl-5,8,11,18-tetraoxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10,17-tetraazadocosanoate

Synonyms: 

Molecular weight: 672.8

CAS: 1135688-15-1

Purity: ≥90%

Formulation: A solid

Application|Immunoprecipitation||Product Type|Biochemicals|Labeling & Detection|Affinity Probes||Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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