Description
An antagonist of neuronal nicotinic AChRs (Ki = 0.055 µM); selective for neuronal nAChRs over muscle-type AChRs (Ki = 70 µM); inhibits acetylcholine-evoked currents in Xenopus oocytes expressing chick α7 subunit-containing nAChRs (IC50 = 95 nM); selective for α7 subunit-containing nAChRs over α6, β2, and β4 subunit-containing nAChRs (Kis = 4.52, 12, and 9.2 µM, respectively); decreases vagus nerve stimulation-induced contractions of isolated guinea pig vagus nerve-stomach preparations (EC50 = 49.4 µM); decreases Egr-1 protein levels in and proliferation of HMEC-Ls; decreases angiogenesis in vitro, ex vivo, and in an H69 SCLC mouse xenograft model at approximately 10 mg/kg per day as well as reduces tumor growth in the H69 SCLC mouse xenograft model
Formal name: N,N,N-triethyl-2-[4-[(1E)-2-phenylethenyl]phenoxy]-ethanaminium, monoiodide
Synonyms:
Molecular weight: 451.4
CAS: 77257-42-2
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cancer|Angiogenesis||Research Area|Neuroscience
