An agonist of muscarinic acetylcholine receptors; induces spasms in isolated intestinal ileum

(±)-Muscarine (hydrate) – 5 mg

Brand:
Cayman
CAS:
2241280-55-5
Storage:
-20
UN-No:
- 2811 / 6.1

(±)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria.{36535} It induces spasms in isolated intestinal ileum from mouse, guinea pig, rabbit, dog, monkey, and horse, contraction of longitudinal uterine and bladder muscle strips from mouse, guinea pig, rabbit, rat, horse, and dog, and slows the heart rate of isolated guinea pig and rabbit atria. In vivo, (±)-muscarine induces bronchoconstriction in guinea pigs and rabbits as well as respiratory depression in rabbits and cats with minimum active doses (MADs) ranging from 1 to 5 μg/kg. It reduces blood pressure in cats, dogs, and rabbits and induces uterine, bladder, and intestinal contraction in cats and dogs. (±)-Muscarine (0.005-0.01 mg/kg) increases circling and pacing behaviors and induces fear aggression in cats.{36536} It has antinociceptive activity in rats in the hot plate and tail-flick tests.{36537} (±)-Muscarine also inhibits acetylcholinesterase (Ki = 220 μM).{36538}  

 

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SKU: 24269 - 5 mg Category:

Description

An agonist of muscarinic acetylcholine receptors; induces spasms in isolated intestinal ileum, contraction of longitudinal uterine and bladder muscle strips, and slows the heart rate of isolated atria from various species; induces bronchoconstriction in guinea pigs and rabbits as well as respiratory depression in rabbits and cats (MADs = 1-5 μg/kg); reduces blood pressure in cats, dogs, and rabbits and induces uterine, bladder, and intestinal contraction in cats and dogs; increases circling and pacing behaviors and induces fear aggression in cats (0.005-0.01 mg/kg); has antinociceptive activity in rats in hot plate and tail-flick tests

Formal name: 2,5-anhydro-1,3,6-trideoxy-1-(trimethylammonio)-ribo-hexitol, monochloride, hydrate

Synonyms: 

Molecular weight: 174.3

CAS: 2241280-55-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience||Research Area|Neuroscience|Pain Research

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