An inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes); inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors (100 μM); neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM

L-trans-Pyrrolidine-2,4-dicarboxylic Acid – 5 mg

Brand:
Cayman
CAS:
64769-66-0
Storage:
-20
UN-No:
Non-Hazardous - /

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes).{40981} It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 (Item No. 10009019) and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX (Item No. 14618).{40982} It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens.{40983} It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats.{40984}  

 

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Description

An inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes); inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors (100 μM); neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively); prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats (0.05-0.2 μg/side in nucleus accumbens); increases bladder ICI in rats

Formal name: 2S,4R-pyrrolidinedicarboxylic acid

Synonyms:  L-trans-2,4-PDC

Molecular weight: 159.1

CAS: 64769-66-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience

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