An NAAA inhibitor (IC50s = 27 and 63 nM for the human and rat enzyme

ARN726 – 25 mg

Brand:
Cayman
CAS:
1628343-77-0
Storage:
-20
UN-No:
Non-Hazardous - /

ARN726 is an inhibitor of N-acylethanolamine acid amidase (NAAA; IC50s = 27 and 63 nM for the human and rat enzyme, respectively).{50197} It is selective for NAAA over fatty acid amide hydrolase (FAAH) and acid ceramidase (IC50s = >100 and 12.5 μM, respectively), as well as a panel of 28 lipid metabolism- and inflammation-related enzymes at 10 μM. ARN726 (1-30 mg/kg) decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. It inhibits NAAA and reverses complete Freund’s adjuvant-induced decreases in palmitoyl ethanolamide (PEA; Item No. 90350) and oleoyl ethanolamide (OEA; Item No. 90265) levels in inflamed paw tissue in a rat model of arthritis.{36896}  

 

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SKU: 24259 - 25 mg Category:

Description

An NAAA inhibitor (IC50s = 27 and 63 nM for the human and rat enzyme, respectively); selective for NAAA over FAAH and acid ceramidase (IC50s = >100 and 12.5 μM, respectively), as well as a panel of 28 enzymes at 10 μM; decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation from 1-30 mg/kg; inhibits NAAA and reverses complete Freund’s adjuvant-induced decreases in PEA and OEA levels in inflamed paw tissue in a rat model of arthritis

Formal name: N-[(3S)-2-oxo-3-azetidinyl]-carbamic acid, 4-cyclohexylbutyl ester

Synonyms: 

Molecular weight: 268.4

CAS: 1628343-77-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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