A major metabolite of the insecticide endosulfan; a persistent organic pollutant; accumulates in the liver and gonads of wild silverside fish; toxic to freshwater fish (LC50s = 2.1-3.5 µg/L after a 96-hour exposure); decreases GSD and MDA in the liver and increases MDA in the kidney of mice at a dose of 3 mg/kg

Endosulfan sulfate – 100 mg

Brand:
Cayman
CAS:
1031-07-8
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Endosulfan sulfate is a major metabolite of endosulfan, a broad-spectrum organochlorine insecticide.{36688} Endosulfan sulfate is formed through oxidation of endosulfan by bacteria and fungi in the environment, where it is considered a persistent organic pollutant (POP). It accumulates in the liver and gonads of wild silverside fish (O. bonariensis) and is found in higher amounts in mature fish than pre-spawning fish.{36689} Levels of endosulfan sulfate in the gills of mature O. bonariensis correlate with increased levels of lipid peroxidation. It is toxic to freshwater fish, including G. affinis, H. formosa, P. latipinna, and P. promelas, with LC50 values ranging from 2.1 to 3.5 µg/L after a 96-hour exposure.{36690} Endosulfan sulfate is the main metabolite found in the liver of mice following endosulfan administration at doses of 0.3 and 3 mg/kg.{36691} It decreases the levels of glutathione (GSH) and malondialdehyde (MDA), a product of lipid peroxidation, in the liver, but increases MDA in the kidney when administered at a dose of 3 mg/kg.  

 

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Description

A major metabolite of the insecticide endosulfan; a persistent organic pollutant; accumulates in the liver and gonads of wild silverside fish; toxic to freshwater fish (LC50s = 2.1-3.5 µg/L after a 96-hour exposure); decreases GSD and MDA in the liver and increases MDA in the kidney of mice at a dose of 3 mg/kg

Formal name: 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin, 3,3-dioxide

Synonyms:  Endosulfan III

Molecular weight: 422.9

CAS: 1031-07-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Toxicology|Drug Metabolism|Drug Metabolites||Research Area|Toxicology|Environmental|Agriculture

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