Description
A potent STAT3 activator and neuroprotective agent; protects approximately 50 and 100% of mouse primary cortical neurons from Aβ1-43-induced cell death at 10 and 100 fM, respectively; protects against V642I-APP-induced cell death in a CaMKIV and STAT3-dependent manner; It increases STAT3 phosphorylation in vitro and in vivo; rescues spatial working memory deficits in a mouse model of Alzheimer’s disease at 10 pmol every six days
Formal name: L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-proline
Synonyms:
Molecular weight: 2,645.10
CAS: 867021-83-8
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection
