A natural apocarotenoid with diverse biological activities; scavenges DPPH radicals (IC50 = 17.8 μg/ml); inhibits growth of MKN28 stomach

Transcrocetin – 5 mg

Brand:
Cayman
CAS:
27876-94-4
Storage:
-20
UN-No:
Non-Hazardous - /

Transcrocetin is a natural apocarotenoid isolated from C. sativus and G. jasminoides that has antioxidant, antiproliferative, anti-inflammatory, cardioprotective, and antinociceptive properties.{41588,41589,41590,41591,41592,41593} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 17.8 μg/ml) and inhibits growth of MKN28 stomach, MCF-7 breast, and Caco-2 colon cancer cell lines (IC50s = 53, 63, and 103 μM, respectively).{41589,41590} Transcrocetin (20 μM) protects primary rat microglial cells from LPS-induced death and decreases LPS-induced production of intracellular reactive oxygen species (ROS), TNF-α, IL-1β, and NF-κB.{41591} Transcrocetin (100 mg/kg) increases the level of glutathione (GSH), catalase (CAT), creatine kinase (CK), and lactate dehydrogenase (LDH) in cardiac tissue in a rat model of myocardial infarction induced by isoproterenol (Item No. 15592).{41592} It also increases the pressure threshold and latency to withdrawal in response to mechanical and thermal stimuli, respectively, indicating a decrease in allodynia in a mouse model of spared nerve injury when administered intrathecally at a dose of 30 mg/kg.{41593}  

 

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Description

A natural apocarotenoid with diverse biological activities; scavenges DPPH radicals (IC50 = 17.8 μg/ml); inhibits growth of MKN28 stomach, MCF-7 breast, and Caco-2 colon cancer cell lines (IC50s = 53, 63, and 103 μM, respectively); protects primary rat microglial cells from LPS-induced death and decreases LPS-induced production of intracellular ROS, TNF-α, IL-1β, and NF-κB (20 μM); increases GSH, CAT, CK, and LDH levels in cardiac tissue in a rat model of isoproterenol-induced myocardial infarction (100 mg/kg); increases the pressure threshold and reaction time to mechanical and thermal allodynia, respectively, in mice with spared nerve injury (30 mg/kg, intrathecal)

Formal name: 2,6,11,15-tetramethyl-2E,4E,6E,8E,10E,12E,14E-hexadecaheptaenedioic acid

Synonyms:  NSC 407300

Molecular weight: 328.4

CAS: 27876-94-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Carotenoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Pain Research

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