A lichen metabolite with diverse biological activities; cytotoxic to HCT116

Diffractaic Acid – 2.5 mg

Brand:
Cayman
CAS:
436-32-8
Storage:
-20
UN-No:
Non-Hazardous - /

Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities.{36882,36883,36884,36885} It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively).{36882} Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 μM).{36883} In vivo, diffractaic acid (25-200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin (Item No. 70270) in rat gastric mucosa.{36884} Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice.{36885}  

 

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SKU: 24208 - 2.5 mg Category:

Description

A lichen metabolite with diverse biological activities; cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively); inhibits growth of M. tuberculosis (MIC = 41.7 μM); reduces indomethacin-induced neutrophil infiltration, lipid peroxidation, MPx activity, and the number of gastric lesions as well as reverses decreases in SOD and GPx activities in rat gastric mucosa from 25-200 mg/kg; reduces acetic acid-induced writhing and increases the pressure pain threshold in mice

Formal name: 2,4-dimethoxy-3,6-dimethyl-benzoic acid, 4-carboxy-3-hydroxy-2,5-dimethylphenyl ester

Synonyms:  NSC 5901|NSC 685595

Molecular weight: 374.4

CAS: 436-32-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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