A selective and reversible proton pump inhibitor; inhibits gastric H+/K+ ATPase (IC50 = 17 nM); does not inhibit porcine Na+/K+ ATPase activity (10 µM); maintains its inhibitory effect in weakly acidic and neutral pH conditions (IC50s = 19 and 28 nM

Vonoprazan (fumarate) – 1 g

Brand:
Cayman
CAS:
1260141-27-2
Storage:
-20
UN-No:
Non-Hazardous - /

Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H+/K+ ATPase (IC50 = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 µM.{40933,40934} It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5) conditions with IC50 values of 19 and 28 nM, respectively. In vivo, vonoprazan (1, 2, and 4 mg/kg) inhibits histamine-stimulated acid secretion in a dose-dependent manner in rats, with complete inhibition when administered at a dose of 4 mg/kg.{40935} It also inhibits acid secretion for more than 48 hours in dogs when administered at doses ranging from 0.1 to 1 mg/kg.  

 

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SKU: 24200 - 1 g Category:

Description

A selective and reversible proton pump inhibitor; inhibits gastric H+/K+ ATPase (IC50 = 17 nM); does not inhibit porcine Na+/K+ ATPase activity (10 µM); maintains its inhibitory effect in weakly acidic and neutral pH conditions (IC50s = 19 and 28 nM, respectively); inhibits histamine-stimulated acid secretion in a dose-dependent manner in rats (1, 2, and 4 mg/kg); inhibits acid secretion for more than 48 hours in dogs (0.1 to 1 mg/kg)

Formal name: 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine, 2-butenedioate

Synonyms:  TAK-438

Molecular weight: 461.5

CAS: 1260141-27-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators

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