Description
An inhibitor of ATR (Ki = 50 = 19 nM in pancreatic cancer cells in vitro); reduces the IC50 of SN-38 by at least 8-fold in vitro when used at a concentration of 80 nM; delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts in mice by 2-3-fold relative to radiation alone (60 mg/kg); enhances the tumoricidal effects of cisplatin against primary human lung cancer xenografts; enhances the effects of irinotecan against COLO 205 colorectal tumors
Formal name: 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine
Synonyms: VX-970
Molecular weight: 463.6
CAS: 1232416-25-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair