Description
A dual PDK1 and class I PI3K inhibitor (IC50s = 245, 56, 446, 35, and 117 nM for PDK1, p110α, p110β, p110δ, and p110γ, respectively); inhibits phosphorylation of T308-PKB (IC50 = 45 nM) in and proliferation of U87MG cells (EC50 = 143 nM); induces cell cycle arrest at the G1 phase in MOLM-14 cells and reduces colony formation by patient-derived AML cells; reduces tumor burden in mice injected with 32D.p210-luc+cells when administered in combination with everolimus
Formal name: α,α-dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
Synonyms: BAG956
Molecular weight: 427.5
CAS: 853910-02-8
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling
