An HCV NS3/4A protease inhibitor (IC50 = 1 nM); selective for NS3/4A over a panel of 53 proteases (10 μM); inhibits replication of the HCV genotypes 1a

Danoprevir – 1 mg

Brand:
Cayman
CAS:
850876-88-9
Storage:
-20
UN-No:
Non-Hazardous - /

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication.{40947} It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).  

 

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SKU: 24185 - 1 mg Category:

Description

An HCV NS3/4A protease inhibitor (IC50 = 1 nM); selective for NS3/4A over a panel of 53 proteases (10 μM); inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro; reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM)

Formal name: 4-fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e] pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester

Synonyms:  ITMN-191|R-7227

Molecular weight: 731.8

CAS: 850876-88-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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