A fluoroquinolone antibiotic; active against P. multocida in vitro (MIC = 0.016 μg/ml); broad-spectrum antibacterial activity mediated by DNA gyrase inhibition against Gram-negative and Gram-positive bacteria (MICs = 0.016-0.4 and 0.19-1.7 µg/ml

Marbofloxacin – 5 g

Brand:
Cayman
CAS:
115550-35-1
Storage:
-20
UN-No:
Non-Hazardous - /

Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).{39533} It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.{39536} In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.{39534} Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.{39535} Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.  

 

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SKU: 24174 - 5 g Category:

Description

A fluoroquinolone antibiotic; active against P. multocida in vitro (MIC = 0.016 μg/ml); broad-spectrum antibacterial activity mediated by DNA gyrase inhibition against Gram-negative and Gram-positive bacteria (MICs = 0.016-0.4 and 0.19-1.7 µg/ml, respectively); prevents pulmonary lesion formation in vivo in a bovine calf model of Mannheimia haemolytica A1 pneumonia (2 mg/kg, i.m.); reduces the parasitic load by 72% in a canine model of leishmaniasis (2 mg/kg per day)

Formal name: 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid

Synonyms: 

Molecular weight: 362.4

CAS: 115550-35-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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