A type II pyrethroid insecticide; modulates Nav channels; binds to Drosophila para Nav channels in a use-dependent manner following brief depolarizing prepulses and with increasing concentrations of 1 to 5 nM; increases proliferation of MCF-7 cells at 10 µM but is not cytotoxic to MCF-7 and CHO cells at 25 and 100 µM; induces transactivation of the androgen receptor at 20 µM but not the estrogen receptor; lethal to mice (LD50 = 50 mg/kg) and induces histopathological changes in the liver

Deltamethrin – 50 mg

Brand:
Cayman
CAS:
52918-63-5
Storage:
-20
UN-No:
- 2811 / 6.1

Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).{36375} It binds to Drosophila para Nav channels in a use-dependent manner following brief depolarizing prepulses and with increasing concentrations of 1 to 5 nM, indicating that it preferentially binds to the channel in the open state.{41828} It slowly activates Nav1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents for channels expressed in X. laevis oocytes.{36375} Deltamethrin decreases proliferation of MCF-7 cells and inhibits androgen receptor transactivation when used at concentrations of 10 and 20 µM or greater, respectively. However, it is not cytotoxic to MCF-7 and CHO cells at concentrations of 25 and 100 µM, respectively, and does not induce transactivation of the estrogen receptor.{41692} Deltamethrin is lethal to mice with an LD50 value of 50 mg/kg and at low sublethal doses of 0.05 and 0.1 mg/kg it induces histopathological changes in the liver, kidney, spleen, and testes, including a loss of spermatozoa and Sertoli cells.{41829}  

 

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Description

A type II pyrethroid insecticide; modulates Nav channels; binds to Drosophila para Nav channels in a use-dependent manner following brief depolarizing prepulses and with increasing concentrations of 1 to 5 nM; increases proliferation of MCF-7 cells at 10 µM but is not cytotoxic to MCF-7 and CHO cells at 25 and 100 µM; induces transactivation of the androgen receptor at 20 µM but not the estrogen receptor; lethal to mice (LD50 = 50 mg/kg) and induces histopathological changes in the liver, kidney, spleen, and testes at low sublethal doses of 0.05 and 0.1 mg/kg

Formal name: (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (S)-cyano(3-phenoxyphenyl)methyl ester

Synonyms:  Decamethrin

Molecular weight: 505.2

CAS: 52918-63-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience||Research Area|Toxicology|Environmental

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