A neuropeptide that is an agonist of NPSR (EC50 = 3.2 nM); increases the duration of wakefulness and decreases SWS1

Neuropeptide S (rat) – 1 mg

Brand:
Cayman
CAS:
412938-75-1
Storage:
-20
UN-No:
Non-Hazardous - /

Neuropeptide S is a neuropeptide that is an agonist of the neuropeptide S receptor (NPSR) with an EC50 value of 3.2 nM for the rat peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor.{14301} In rats, it increases the duration of wakefulness and decreases slow wave sleep stage 1 (SWS1), SWS2, and rapid eye movement (REM). Neuropeptide S dose-dependently (0.5-4 nmol per animal, i.c.v.) decreases fecal pellet excretion induced by restraint stress or corticotropin releasing factor (CRF) but does not influence basal gastric emptying, gastrointestinal transit, or distal colon propulsion.{40683} It also inhibits audible and ultrasonic vocalizations and increases the percentage of time spent in the open arm of the elevated plus maze test in a mouse model of arthritis.{40684}  

 

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SKU: 24148 - 1 mg Category:

Description

A neuropeptide that is an agonist of NPSR (EC50 = 3.2 nM); increases the duration of wakefulness and decreases SWS1, SWS2, and REM sleep in rats; dose-dependently (0.5-4 nmol per animal, i.c.v.) decreases fecal pellet excretion induced by restraint stress or CRF; nasal administration inhibits audible and ultrasonic vocalizations and has anxiolytic-like effects in the elevated plus-maze test in a mouse model of arthritis

Formal name: L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-serylglycyl-L-valyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-arginyl-L-arginyl-L-alanyl-L-lysyl-L-glutamine

Synonyms:  NPS

Molecular weight: 2,210.50

CAS: 412938-75-1

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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