A D2 receptor antagonist and antiemetic; prevents apomorphine-induced emesis in dogs when administered at a dose of 20 mg/kg; stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 μg/mL); decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes when used at a dose of 20 mg/kg; enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats

Trimethobenzamide (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
554-92-7
Storage:
-20
UN-No:
Non-Hazardous - /

Trimethobenzamide is a dopamine D2 receptor antagonist and antiemetic.{41366} It prevents emesis induced by the dopamine agonist apomorphine (Item No. 16094) in dogs when used at a dose of 20 mg/kg and stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 μg/mL).{41368} Trimethobenzamide (20 mg/kg) decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes.{41367} Trimethobenzamide (6.7 g/kg per day for 2 weeks) enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury.{41369} Formulations containing trimethobenzamide have been used to treat nausea and vomiting.  

 

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SKU: 24145 - 250 mg Category:

Description

A D2 receptor antagonist and antiemetic; prevents apomorphine-induced emesis in dogs when administered at a dose of 20 mg/kg; stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 μg/mL); decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes when used at a dose of 20 mg/kg; enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury, when administered at a dose of 6.7 g/kg per day for 2 weeks

Formal name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-benzamide, monohydrochloride

Synonyms:  Ro 2-9578

Molecular weight: 424.9

CAS: 554-92-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience

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