An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli

Methidathion – 100 mg

Brand:
Cayman
CAS:
950-37-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Methidathion is an organophosphate insecticide that inhibits insect cholinesterase.{42230} It reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% when administered topically at a dose of 3.5 mg/kg.{42226} Methidathion is selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival when administered topically at a dose of 24 mg/kg. It increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells when used at a concentration of 40 μg/ml.{42227} Dietary administration of methidathion (1.4-4.7 mg/kg) increases alanine aminotransferase, aspartate aminotransferase, sorbitol dehydrogenase, and alkaline phosphatase activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs.{42228} It also induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats when administered orally at a dose of 5 mg/kg.{42229}  

 

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SKU: 24144 - 100 mg Category:

Description

An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% at 3.5 mg/kg; selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival at 24 mg/kg; increases SCE and induces cell cycle arrest at the M1 phase in V79 cells at 40 μg/ml; increases liver enzyme activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs from 1.4-4.7 mg/kg; induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats 5 mg/kg ,

Formal name: S-[(5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl]phosphorodithioic acid, O,O-dimethyl ester

Synonyms: 

Molecular weight: 302.3

CAS: 950-37-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Cycle||Research Area|Toxicology|Environmental

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