An insecticide; inhibits chitin synthesis by 35% in N. lugens nymphs at 10 ppm; decreases the lifespan of adult T. vaporariorum with 17.9% mortality after 24 hours at 500 ppm; shifts energy metabolism from TCA to glycolysis and increases production of ROS in HepG2 cells; not mutagenic with LD50 values of 6

Buprofezin – 50 mg

Brand:
Cayman
CAS:
69327-76-0
Storage:
-20
UN-No:
Non-Hazardous - /

Buprofezin is an insecticide that acts by inhibiting chitin synthesis.{39785} It inhibits chitin synthesis by 35% in N. lugens nymphs when used at a concentration of 10 ppm. Buprofezin (500 ppm) decreases the lifespan of adult T. vaporariorum with 17.9% mortality after 24 hours.{39786} It inhibits mitochondrial respiration when used at concentrations of 10 and 30 µM, reduces the expression of enzymes involved in the tricarboxylic acid (TCA) cycle, and stimulates glycolysis in HepG2 cells.{39787} It also dose-dependently increases the production of reactive oxygen species (ROS) in vitro. Buprofezin accumulates in mouse liver following oral administration of doses ranging from 46.3 to 417 mg/kg. It is not mutagenic and has LD50 values of 6,810 and 5,010 mg/kg in male and female rats, respectively.{39800} Formulations containing buprofezin have been used as insecticides.  

 

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SKU: 24137 - 50 mg Category:

Description

An insecticide; inhibits chitin synthesis by 35% in N. lugens nymphs at 10 ppm; decreases the lifespan of adult T. vaporariorum with 17.9% mortality after 24 hours at 500 ppm; shifts energy metabolism from TCA to glycolysis and increases production of ROS in HepG2 cells; not mutagenic with LD50 values of 6,810 and 5,010 mg/kg in male and female rats, respectively; accumulates in mouse liver at oral doses ranging from 46.3 to 417 mg/kg

Formal name: 2-[(1,1-dimethylethyl)imino]tetrahydro-3-(1-methylethyl)-5-phenyl-4H-1,3,5-thiadiazin-4-one

Synonyms:  NNI-750

Molecular weight: 305.4

CAS: 69327-76-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Environmental

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