An activator of STING; induces expression of IFN-β and the pro-inflammatory cytokines TNF-α

ML RR-S2 CDA (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
1638750-96-5
Storage:
-20
UN-No:
Non-Hazardous - /

ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2’5′-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).{38806} It contains mixed linkages (ML) with both 2’5′ and 3’5′ linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; Item No. 17753), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models.  

 

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SKU: 24106 - 1 mg Category:

Description

An activator of STING; induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine BMMs isolated from wild-type, but not STING-/-, mice; induces IFN-β expression in PBMCs isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles; initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models,

Formal name: [P(R)]-5′-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2’→5′)-adenosine, cyclic nucleotide, diammonium salt

Synonyms:  STING Inducer-1

Molecular weight: 724.6

CAS: 1638750-96-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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