A diterpenoid furanolactone with diverse biological activities; inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice (25 mg/kg per day for 3 days); selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM

Columbin – 1 mg

Brand:
Cayman
CAS:
546-97-4
Storage:
-20
UN-No:
Non-Hazardous - /

Columbin is a diterpenoid furanolactone isolated from J. columba, A. albida, and T. bakis that has diverse biological activities.{38835,38836,38837,38838} It inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice when administered at a dose of 25 mg/kg per day for three days.{38835} Columbin selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM, respectively) and reduces carrageenan-induced paw edema in rats in a dose-dependent manner.{38836} Dietary feeding of columbin (4, 20, and 100 ppm) reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis.{38837} Columbin (20-40 mg/kg per day) also reduces sleeping time induced by a mixture of urethane and α-choralose but prolongs sleeping time induced by hexobarbital in mice.{38838}  

 

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Description

A diterpenoid furanolactone with diverse biological activities; inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice (25 mg/kg per day for 3 days); selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM, respectively); reduces carrageenan-induced paw edema in rats; reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis (4, 20, and 100 ppm, dietary); reduces urethane and reduces sleeping time induced by a mixture of urethane and α-choralose but prolongs hexobarbital-induced sleeping time in mice,

Formal name: 9-(3-furanyl)-1R,4R,4aR,5,6,6aR,9S,10,10aS,10bS-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c’]dipyran-3,7-dione

Synonyms: 

Molecular weight: 358.4

CAS: 546-97-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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