A semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria; inhibits the growth of clinical isolates of MRSA

Oritavancin (phosphate) – 50 mg

Brand:
Cayman
CAS:
192564-14-0
Storage:
-20
UN-No:
Non-Hazardous - /

Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria.{39468} It inhibits transglycosylation and transpeptidation in the bacterial cell wall to disrupt membrane integrity.{39469,39470} Oritavancin inhibits the growth of clinical isolates from skin and soft-tissue infections, including methicillin-resistant and -susceptible S. aureus (MRSA, MSSA), vancomycin-resistant and -susceptible E. faecium (VREF, VSRF), as well as other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L).{39471} Oritavancin inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for a single dose).{39472} It improves survival in a mouse inhalation model of B. anthracis Ames anthrax when administered prophylactically pre- and postexposure and when administered post symptom development.{39473} Formulations containing oritavancin have been used to treat bacterial skin infections.  

 

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SKU: 24091 - 50 mg Category:

Description

A semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria; inhibits the growth of clinical isolates of MRSA, MSSA, VREF, VSRF, and other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L); inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for single dose); improves survival of mice in an inhalation model of B. anthracis Ames anthrax

Formal name: (4″R)-22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3″-[(4′-chloro[1,1′-biphenyl]-4-yl)methyl]-vancomycin, diphosphate

Synonyms:  LY 333328

Molecular weight: 1,989.10

CAS: 192564-14-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Glycopeptides & Lipoglycopeptides||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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