Description
A somatostatin receptor agonist with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100nM, respectively); inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro when used at a concentration of 100 nM; inhibits tumor growth in SCLC mouse xenograft models when administered at a dose of 250 µg, twice daily
Formal name: 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-cyclic (2→7)-disulfide, L-threoninamide, acetate
Synonyms: BIM23014
Molecular weight: 1,096.30
CAS: 127984-74-1
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neuroendocrinology
