A somatostatin receptor agonist with a higher affinity for the somatostatin subgroup 2 receptors SST2

Lanreotide (acetate) – 10 mg

Brand:
Cayman
CAS:
127984-74-1
Storage:
-20
UN-No:
Non-Hazardous - /

Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).{36315} Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro.{36316} It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily.{36317} Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.  

 

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SKU: 24084 - 10 mg Category:

Description

A somatostatin receptor agonist with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100nM, respectively); inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro when used at a concentration of 100 nM; inhibits tumor growth in SCLC mouse xenograft models when administered at a dose of 250 µg, twice daily

Formal name: 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-cyclic (2→7)-disulfide, L-threoninamide, acetate

Synonyms:  BIM23014

Molecular weight: 1,096.30

CAS: 127984-74-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neuroendocrinology

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