A broad-spectrum fungicide (LC95s = 20 = 2.9 µM); disrupts mRNA expression of antioxidant-

Azoxystrobin – 50 mg

Brand:
Cayman
CAS:
131860-33-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide (LC95s = o site of the cytochrome bc1 complex and inhibiting electron transfer.{36648} Azoxystrobin is cytotoxic to MDA-kb2 cells with an EC20 value of 2.9 µM but has no antiandrogenic activity.{42005} It disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of reactive oxygen species (ROS) in zebrafish larva when used at doses ranging from 0.1 to 100 µg/L.{36649} Azoxystrobin inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours) and induces apoptosis in a time- and dose-dependent manner.{36650} In a KYSE-150 nude mouse xenograft model, azoxystrobin reduces tumor growth when administered at a dose of 40 mg/kg per day.  

 

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SKU: 24056 - 50 mg Category:

Description

A broad-spectrum fungicide (LC95s = 20 = 2.9 µM); disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of ROS in zebrafish larva at 0.1-100 µg/L; inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours); reduces tumor growth at 40 mg/kg per day

Formal name: 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-αE-(methoxymethylene)-benzeneacetic acid, methyl ester

Synonyms:  ICI-A 5504

Molecular weight: 403.4

CAS: 131860-33-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology||Research Area|Plant Biology||Research Area|Toxicology|Environmental

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