A triazole antifungal; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; inhibits the growth of F. graminearum isolates in vitro (EC50s = 1.69-19.6 mg/L for mycelial growth); inhibits growth of A. sonali

Difenoconazole – 50 mg

Brand:
Cayman
CAS:
119446-68-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.{30331,39666} It inhibits the growth of F. graminearum isolates in vitro (EC50s = 1.69-19.6 mg/L for mycelial growth).{39666} It also inhibits growth of A. sonali, F. fulva, B. cinerea, and R. solani (EC50s = 0.131, 0.069, 0.297, and 0.252 mg/L, respectively).{39667} Difenoconazole reduces germtube growth of A. caricae, the mold responsible for black spot in papaya plants (EC50 = 2 ppm).{39668} It exhibits acute aquatic toxicity, reducing growth of S. obliquus algae (EC50 = 1.338 μg/ml) and decreasing survival of D. magna (LD50 = 0.298 μg/ml).{39667} Difenoconazole is also lethal to zebrafish (D. rerio) embryos, larvae, and adults (LC50s = 2.34, 1.17, and 1.45 mg/L, respectively).{39669} At sub-LC50 concentrations, difenoconazole induces pericardial and yolk sac edema in zebrafish embryos, body blackening and slowed heart rate in larvae, and decreased body weight and length in adults.  

 

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Description

A triazole antifungal; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; inhibits the growth of F. graminearum isolates in vitro (EC50s = 1.69-19.6 mg/L for mycelial growth); inhibits growth of A. sonali, F. fulva, B. cinerea, and R. solani (EC50s = 0.131, 0.069, 0.297, and 0.252 mg/L, respectively); reduces germtube growth of A. caricae (EC50 = 2 ppm); lethal to zebrafish embryos, larvae, and adults (LC50s = 2.34, 1.17, and 1.45 mg/L, respectively); induces pericardial and yolk sac edema in zebrafish embryos, body blackening and slowed heart rate in larvae, and decreased body weight and length in adults,

Formal name: 1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole

Synonyms:  CGA 169374

Molecular weight: 406.3

CAS: 119446-68-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cell Biology||Research Area|Plant Biology||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Environmental

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