Description
A triazole fungicide; inhibits 14α-demethylase isolated from U. maydis and S. bicolor (IC50s = 0.05 and 0.16 nM, respectively); inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in a MDA-kb2 assay; reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses following gestational administration (50 and 100 mg/kg per day); gestational and postnatal administration to rats leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning in the Morris water maze (20 and 60 mg/kg per day)
Formal name: α-[2-(4-chlorophenyl)ethyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol
Synonyms: BAY HWG-1608
Molecular weight: 307.8
CAS: 107534-96-3
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Environmental
