An imidazole antifungal; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM); ER and AR antagonist (IC50s = 25 and 4 μM

Prochloraz – 100 mg

Brand:
Cayman
CAS:
67747-09-5
Storage:
-20
UN-No:
- / 9

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.{41691} It inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM).{30331} Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).{41692} In vivo, prochloraz (250 mg/kg) reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats.{41693} It also reduces testosterone levels and increases progesterone levels in male rat pups following administration of a 30 mg/kg per day dose to pregnant females during gestation. Formulations containing prochloraz have been used to control fungal growth in mushroom cultivation.  

 

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SKU: 24051 - 100 mg Category:

Description

An imidazole antifungal; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM); ER and AR antagonist (IC50s = 25 and 4 μM, respectively); activates AhR (EC50 = 1 μM); reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats (250 mg/kg); reduces testosterone levels and increases progesterone levels in male rat pups (30 mg/kg per day to pregnant females)

Formal name: N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide

Synonyms:  BTS-40542

Molecular weight: 376.7

CAS: 67747-09-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antifungals|Imidazoles||Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Environmental|Agriculture

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