An inhibitor of Factor Xa (IC50s = 40

Fondaparinux (sodium salt) – 5 mg

Brand:
Cayman
CAS:
114870-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

Fondaparinux is a pentasaccharide inhibitor of Factor Xa, the enzyme that activates prothrombin in the coagulation cascade (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively, in vitro).{38580} It binds to antithrombin III (Kds = 48, 132, 78, and 50 nM for human, rabbit, baboon, and rat, respectively) and inhibits thrombin generation through the extrinsic and intrinsic routes (IC50s = 0.3 and 2.8 µM, respectively). Fondaparinux dose-dependently inhibits thrombus formation in a rabbit model of venous thrombosis with complete inhibition of clot formation at a dose of 200 µg/kg. Formulations containing fondaparinux have been used for prophylaxis of deep vein thrombosis following hip or knee replacement surgery.  

 

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SKU: 24033 - 5 mg Category:

Description

An inhibitor of Factor Xa (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively); binds to antithrombin III (Kds = 48, 132, 78, and 50 nM for human, rabbit, baboon, and rat, respectively); inhibits thrombin generation through the extrinsic and intrinsic routes (IC50s = 0.3 and 2.8 µM, respectively); dose-dependently inhibits thrombus formation in a rabbit model of venous thrombosis with complete inhibition of clot formation at a dose of 200 µg/kg

Formal name: methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-α-D-glucopyranoside, 6-(hydrogen sulfate), decasodium salt

Synonyms:  SR 90107A

Molecular weight: 1,728.00

CAS: 114870-03-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis

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